1,581 research outputs found
Adrenomedullin expression in the mouse mammary gland: evidence for the mature form in milk
Adrenomedullin (AM) is a recently identified amidated peptide produced by a variety of tissue types. We have investigated the involvement of AM and its receptor (AM-R) in developing mouse mammary glands and have examined what influence ovarian hormones have on AM and AM-R expression in this system. Tissues from ductal morphogenesis, virgin adult, pregnancy, and lactation stages were assessed for AM and AM-R by molecular, biochemical and immunohistochemical techniques. Results from these studies indicated that messenger RNA for AM and AM-R and immunoreactivity for AM were expressed in the luminal epithelium of small and large ducts and in terminal end buds. Immunoreactive AM was identified as a cytoplasm component of ductal cells, with some cells also having nuclear staining. Western blot analysis of mammary gland tissues yielded two molecular mass species (M(r) 14,000 and 18,500) of AM immunoreactivity in the mammary gland for the above developmental stages, consistent with processed intermediate and prohormone forms respectively. Ovariectomy alone or followed by hormonal treatments did not alter the expression pattern for these two proteins. By Western blot, the fully processed AM form (M(r) 6000) was identified in milk extracts from lactating glands. These data suggest a potential role for AM and its receptor in the maintenance of mammary gland homeostasis and suggests a potential role for AM in development of the newborn
Constraints on the pMSSM from LAT Observations of Dwarf Spheroidal Galaxies
We examine the ability for the Large Area Telescope (LAT) to constrain
Minimal Supersymmetric Standard Model (MSSM) dark matter through a combined
analysis of Milky Way dwarf spheroidal galaxies. We examine the Lightest
Supersymmetric Particles (LSPs) for a set of ~71k experimentally valid
supersymmetric models derived from the phenomenological-MSSM (pMSSM). We find
that none of these models can be excluded at 95% confidence by the current
analysis; nevertheless, many lie within the predicted reach of future LAT
analyses. With two years of data, we find that the LAT is currently most
sensitive to light LSPs (m_LSP < 50 GeV) annihilating into tau-pairs and
heavier LSPs annihilating into b-bbar. Additionally, we find that future LAT
analyses will be able to probe some LSPs that form a sub-dominant component of
dark matter. We directly compare the LAT results to direct detection
experiments and show the complementarity of these search methods.Comment: 24 pages, 9 figures, submitted to JCA
Shear Viscosity in the O(N) Model
We compute the shear viscosity in the O(N) model at first nontrivial order in
the large N expansion. The calculation is organized using the 1/N expansion of
the 2PI effective action (2PI-1/N expansion) to next-to-leading order, which
leads to an integral equation summing ladder and bubble diagrams. We also
consider the weakly coupled theory for arbitrary N, using the three-loop
expansion of the 2PI effective action. In the limit of weak coupling and
vanishing mass, we find an approximate analytical solution of the integral
equation. For general coupling and mass, the integral equation is solved
numerically using a variational approach. The shear viscosity turns out to be
close to the result obtained in the weak-coupling analysis.Comment: 37 pages, few typos corrected; to appear in JHE
A novel determination of the local dark matter density
We present a novel study on the problem of constructing mass models for the
Milky Way, concentrating on features regarding the dark matter halo component.
We have considered a variegated sample of dynamical observables for the Galaxy,
including several results which have appeared recently, and studied a 7- or
8-dimensional parameter space - defining the Galaxy model - by implementing a
Bayesian approach to the parameter estimation based on a Markov Chain Monte
Carlo method. The main result of this analysis is a novel determination of the
local dark matter halo density which, assuming spherical symmetry and either an
Einasto or an NFW density profile is found to be around 0.39 GeV cm with
a 1- error bar of about 7%; more precisely we find a for the Einasto profile and for the NFW. This is in contrast to the
standard assumption that is about 0.3 GeV cm with an
uncertainty of a factor of 2 to 3. A very precise determination of the local
halo density is very important for interpreting direct dark matter detection
experiments. Indeed the results we produced, together with the recent accurate
determination of the local circular velocity, should be very useful to
considerably narrow astrophysical uncertainties on direct dark matter
detection.Comment: 31 pages,11 figures; minor changes in the text; two figures adde
Constraints on Decaying Dark Matter from Fermi Observations of Nearby Galaxies and Clusters
We analyze the impact of Fermi gamma-ray observations (primarily
non-detections) of selected nearby galaxies, including dwarf spheroidals, and
of clusters of galaxies on decaying dark matter models. We show that the fact
that galaxy clusters do not shine in gamma rays puts the most stringent limits
available to-date on the lifetime of dark matter particles for a wide range of
particle masses and decay final states. In particular, our results put strong
constraints on the possibility of ascribing to decaying dark matter both the
increasing positron fraction reported by PAMELA and the high-energy feature in
the electron-positron spectrum measured by Fermi. Observations of nearby dwarf
galaxies and of the Andromeda Galaxy (M31) do not provide as strong limits as
those from galaxy clusters, while still improving on previous constraints in
some cases.Comment: 27 pages, 5 figures, submitted to JCAP, revised version with some
additions and correction
A New Approach to Searching for Dark Matter Signals in Fermi-LAT Gamma Rays
Several cosmic ray experiments have measured excesses in electrons and
positrons, relative to standard backgrounds, for energies from ~ 10 GeV - 1
TeV. These excesses could be due to new astrophysical sources, but an
explanation in which the electrons and positrons are dark matter annihilation
or decay products is also consistent. Fortunately, the Fermi-LAT diffuse gamma
ray measurements can further test these models, since the electrons and
positrons produce gamma rays in their interactions in the interstellar medium.
Although the dark matter gamma ray signal consistent with the local electron
and positron measurements should be quite large, as we review, there are
substantial uncertainties in the modeling of diffuse backgrounds and,
additionally, experimental uncertainties that make it difficult to claim a dark
matter discovery. In this paper, we introduce an alternative method for
understanding the diffuse gamma ray spectrum in which we take the intensity
ratio in each energy bin of two different regions of the sky, thereby canceling
common systematic uncertainties. For many spectra, this ratio fits well to a
power law with a single break in energy. The two measured exponent indices are
a robust discriminant between candidate models, and we demonstrate that dark
matter annihilation scenarios can predict index values that require "extreme"
parameters for background-only explanations.Comment: v1: 11 pages, 7 figures, 1 table, revtex4; v2: 13 pages, 8 figures, 1
table, revtex4, Figure 4 added, minor additions made to text, references
added, conclusions unchanged, published versio
Direct Constraints on Minimal Supersymmetry from Fermi-LAT Observations of the Dwarf Galaxy Segue 1
The dwarf galaxy Segue 1 is one of the most promising targets for the
indirect detection of dark matter. Here we examine what constraints 9 months of
Fermi-LAT gamma-ray observations of Segue 1 place upon the Constrained Minimal
Supersymmetric Standard Model (CMSSM), with the lightest neutralino as the dark
matter particle. We use nested sampling to explore the CMSSM parameter space,
simultaneously fitting other relevant constraints from accelerator bounds, the
relic density, electroweak precision observables, the anomalous magnetic moment
of the muon and B-physics. We include spectral and spatial fits to the Fermi
observations, a full treatment of the instrumental response and its related
uncertainty, and detailed background models. We also perform an extrapolation
to 5 years of observations, assuming no signal is observed from Segue 1 in that
time. Results marginally disfavour models with low neutralino masses and high
annihilation cross-sections. Virtually all of these models are however already
disfavoured by existing experimental or relic density constraints.Comment: 22 pages, 5 figures; added extra scans with extreme halo parameters,
expanded introduction and discussion in response to referee's comment
Implications of the Fermi-LAT diffuse gamma-ray measurements on annihilating or decaying Dark Matter
We analyze the recently published Fermi-LAT diffuse gamma-ray measurements in
the context of leptonically annihilating or decaying dark matter (DM) with the
aim to explain simultaneously the isotropic diffuse gamma-ray and the PAMELA,
Fermi and HESS (PFH) anomalous data. Five different DM
annihilation/decay channels , , , , or (the latter
two via an intermediate light particle ) are generated with PYTHIA. We
calculate both the Galactic and extragalactic prompt and inverse Compton (IC)
contributions to the resulting gamma-ray spectra. To find the Galactic IC
spectra we use the interstellar radiation field model from the latest release
of GALPROP. For the extragalactic signal we show that the amplitude of the
prompt gamma-emission is very sensitive to the assumed model for the
extragalactic background light. For our Galaxy we use the Einasto, NFW and
Isothermal DM density profiles and include the effects of DM substructure
assuming a simple subhalo model. Our calculations show that for the
annihilating DM the extragalactic gamma-ray signal can dominate only if rather
extreme power-law concentration-mass relation is used, while more
realistic relations make the extragalactic component comparable or
subdominant to the Galactic signal. For the decaying DM the Galactic signal
always exceeds the extragalactic one. In the case of annihilating DM the PFH
favored parameters can be ruled out only if power-law relation is
assumed. For DM decaying into or the PFH favored DM parameters
are not in conflict with the Fermi gamma-ray data. We find that, due to the
(almost) featureless Galactic IC spectrum and the DM halo substructure,
annihilating DM may give a good simultaneous fit to the isotropic diffuse
gamma-ray and to the PFH data without being in clear conflict with the
other Fermi-LAT gamma-ray measurements.Comment: Accepted for publication in JCAP, added missing references, new Figs.
9 \& 10, 35 page
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